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1. In the early stages of chronic nephritis, when diagnosis is difficult, it is usually normal.
2. It is low in chronic interstitial nephritis, diabetes insipidus, and many functional nervous disorders.
3. In acute and chronic parenchymatous nephritis the quantity is usually very large.
4. In chronic interstitial nephritis it is small—frequently no more than a trace.
5. Waxy casts are found in most advanced cases of nephritis, where they are an unfavorable sign.