Biochemistry, Physiology. a heterocyclic amine, C5H9N3, released by mast cells when tissue is injured or in allergic and inflammatory reactions, causing dilation of small blood vessels and smooth muscle contraction.
Pharmacology. a commercial form of this compound, obtained from histidine and used chiefly in the diagnosis of gastric and circulatory functions.
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People with histamine allergies may even experience headaches, though probably not as severe as the migraines that can be triggered by cogeners, says Bonci.